Drago Carmelo

Drago Carmelo

    • Researchers
  • 31 Ottobre 2014
  • 1115

PERSONAL DETAILS


Profile: Ricercatore

Office location: Catania

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Work phone #: +390957338350

Lab phone #: +39095733364

Biography:

Dr Carmelo Drago commenced his studies in Chemistry at the University of Catania in September 1995. He graduated on December 21st 2001 (Mark: First Class Honours, 110/110). In April 2002, he moved to the University of Sheffield (U.K.) where he started his PhD working on a project entitled “Combinatorial Approaches to Catalysis for Asymmetric Sulfide Oxidation” under the supervision of Prof. R. F. W. Jackson. As part of his PhD, he carried out research work in the Organic Chemistry Department of the University of Cologne (Germany) working on a project titled “Approaches to Infrared Thermography Screening of Heterogeneous Catalysts Libraries“. In December 2005, he moved to the CISI (Centre for Bio-molecular Interdisciplinary Studies and Industrial applications) which is Centre of Excellence of the University of Milan, where he started working on a project “Design, synthesis and biological screening of libraries of molecules obtained using high throughput techniques starting from original structural unities, for both diagnostic and therapeutic applications”. In March 2011, he moved to the Nanotechnologies Laboratory within the Institute of Molecular Science and Technologies of the National Research Council (Milan), where he started working as a researcher on a project entitled “Synthesis, design and characterization of SPIO nanoparticles conjugated to biomolecules developed from original structural units for therapeutic and diagnostic applications”. Since November 2011, he is working as a permanent researcher (matric.: 14514) at the Institute of Biomolecular Chemistry of the National Research Council (Catania) where is mainly involved on a research project entitled “Sustainable synthesis and optimization of novel biofuels and biofuel additives from renewable feedstock”.


SCIENTIFIC ACTIVITIES


Interests

Sustainable synthesis and optimization of novel biofuels and biofuel additives from renewable feedstock  

Development of sustainable catalytic processes and synthesis of bioactive molecules

Synthesis, design and characterization of SPIO nanoparticles conjugated to biomolecules developed from original structural units for therapeutic and diagnostic applications

Design, synthesis and biological screening methods through high yield synthesis of combinatorial libraries of molecules developed from original structural units, for therapeutic and diagnostic applications

Major publications

  1. Magnetic nanoparticles conjugated to chiral imidazolidinone as recoverable catalys; Sara Mondini, Alessandra Puglisi, Maurizio Benaglia, Daniela Ramella, Carmelo Drago, Anna M. Ferretti, and Alessandro Ponti, J Nanopart Res (2013) 15:2025
  2. One-pot microwave assisted catalytic transformation of vegetable oil into glycerol-free Biodiesel; C. Drago, L. F. Liotta, V. La Parola, M. L. Testa and G. Nicolosi; Fuel, 2013, 113, 707
  3. Bisphosphonate-functionalized cyclic Arg-Gly-Asp peptidomimetics; Carmelo Drago, Daniela Arosio, Cesare Casgrande, and Leonardo Manzoni; ARKIVOC 2013, 18
  4. Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization; Pierfausto Seneci, Laura Belvisi, Martino Bolognesi, Monica Civera, Federica Cossu, Michelandrea De Cesare, Domenico Delia, Carmelo Drago, Daniele Lecis, Leonardo Manzoni, Eloise Mastrangelo, Mario Milani, Elisabetta Moroni, Paola Perego, Donatella Potenza, Vincenzo Rizzo, Cinzia Scavullo, Federica Servida, Francesca Vasile and Carlo Scolastico; Bioorganic & Medicinal Chemistry, 2012, 20, 6709
  5.  Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis; Pierfausto Seneci, Laura Belvisi, Aldo Bianchi, Martino Bolognesi, Carmelo Drago, Domenico Delia, Marilenia de Matteo, Luca Ferrante, Leonardo Manzoni, Paola Perego, Donatella Potenza, Vincenzo Rizzo, Federica Servida, Gabriele Timpano, Francesca Vasile and Carlo Scolastico; Bioorganic & Medicinal Chemistry, 2012, 20, 6687
  6. Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib, D. Lecis, C. Drago, L. Manzoni, P. Seneci, C. Scolastico, E. Mastrangelo, M. Bolognesi, A. Anichini, H. Kashkar, H. Walczak and D. Delia, British Journal of Cancer, 2010, 102, 1707
  7. Rational design, synthesis and characterization of potent, non-peptidic SMAC mimics/XIAP inhibitors as proapoptotic agent for cancer therapy, Pierfausto Seneci, Aldo Bianchi, Cristina Battaglia, Laura Belvisi, Martino Bolognesi, Andrea Caprini, Federica Cossu, Elena de Franco, Marilenia De Matteo, Domenico Delia, Carmelo Drago, Daniele Lecis, Leonardo Manzoni, Eloise Mastrangelo, Mario Milani, Ilaria Motto, Donatella Potenza, Vincenzo Rizzo, Federica Servida, Elisa Turlizzi, Maurizio Varrone, Francesca Vasile, and Carlo Scolastico, Bioorganic & Medicinal Chemistry, 2009, 17, 5834
  8. Enantioselective oxidation of a alkyl aryl sulfide: Synthesis of (S)-(-)-Methyl p-bromophenyl sulfoxide, C. Drago, E. Walker, L. Caggiano and R.F.W. Jackson, Organic Syntheses, 2009, 86, 121.  
  9. mimetics. Structure, activity and recognition principles, Eloise Mastrangelo, Federica Cossu, Mario Milani, Graziella Sorrentino, Daniele Lecis, Domenico Delia, Leonardo Manzoni, Carmelo Drago, Pierfausto Seneci, Carlo Scolastico, Vincenzo Rizzo and Martino Bolognesi, Journal of Biological Chemistry, 2008, 384, 673. 
  10. A Vanadium-catalysed Sulfur Oxidation/Kinetic Resolution Process for the Synthesis of Enantiomerically Pure Alkyl Aryl Sulfoxides, Carmelo Drago, Lorenzo Caggiano, and Richard F.W. Jackson, Angewandte-Chemie International Edition, accepted as VIP, 2005, 44, 7221

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